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Katogen Sentinel™Real-time catalyst and risk monitoring for the assets, companies, disease areas, and technologies that matter most to you.
Built directly on the Katogen Engine, Sentinel turns static strategic reports into persistent, intelligent Watches - delivering operator-vetted alerts ranked by impact level to your inbox daily or weekly.
Never miss a regulatory filing, clinical readout, deal announcement, or competitive move again. Same 101 official sources as Engine and BoardMemos—with entity verification before any alert fires.
Static reports go stale the day they are printed.
Sentinel keeps your intelligence alive - surfacing only the signals that move the needle, ranked and explained by an operator who has sat in the CEO seat for 2 decades.
Process
How it works
- 1
Create a Watch from Engine or Sentinel
Spin up from any Engine report (company, asset, disease area, or technology) or build custom Watches directly in Sentinel.
- 2
Sentinel monitors thousands of sources in real time
Public and structured feeds are continuously scanned so you are not rewiring spreadsheets every Monday.
- 3
Receive prioritized, operator-vetted alerts
Email digests surface severity, impact, and actionability - with links back to refreshed Engine analysis when you need depth.
Differentiation
Why Sentinel is different
Persistent Watches
Across companies, disease areas, and technologies - intelligence stays alive after the PDF ships.
Operator-vetted alert ranking
Severity, impact, and actionability - ranked so your inbox stays signal, not noise.
Live signal dashboard
Historical alert timeline plus one-click refresh of the underlying Engine reports.
Automated deep-dive regeneration
Any alert can pull the latest analysis so you are never debating stale narrative.
Seamless Engine + Sentinel synergy
One click turns any Engine deliverable into a live Watch.
Custom alert filters
Tune by company, disease area, and technology.
Official sources first
Katogen source stack
Sentinel monitors each watch against the same multi-source stack as Engine—FDA announcements, trial registries, ingested regulatory records, issuer filings, and bounded web—then applies entity verification. No anchored sources → no alert.
101 official sources (76 on a refresh schedule · 24 live on every run · 1 biotech issuer filing index) · see full source catalog
FDA & US drugsCRLs, Drugs@FDA, labels, expedited designations, AdCom, inspections, safety comms, and press RSS.
21 sources — show list
- CDC ACIP — vaccine recommendations(CDC)
- DailyMed / drug labeling (openFDA)(FDA)
- DEA — controlled substance scheduling(DEA)
- Drugs@FDA applications (openFDA)(FDA)
- FAERS adverse events (bounded openFDA)(FDA)
- FDA advisory committee calendar(FDA)
- FDA AI / SaMD policy (CDRH)(FDA)
- FDA CDRH — device guidance(FDA)
- FDA complete response letters (openFDA)(FDA)
- FDA drug safety communications(FDA)
- FDA expedited designations (OOPD)(FDA)
- FDA import refusals & alerts(FDA)
- FDA inspections & 483s (openFDA enforcement)(FDA)
- FDA Office of Combination Products(FDA)
- FDA Oncology Center of Excellence(FDA)
- FDA press releases (RSS)(FDA)
- FDA quality & enforcement actions(FDA)
- FDA Sentinel public RWE reports(FDA)
- FDA-related litigation dockets (bounded)(FDA)
- IND critical path operator framing(FDA)
- OHRP — human subjects / Common Rule(OHRP)
TrialsClinicalTrials.gov live API plus EU CTIS index excerpts.
2 sources — show list
SEC & capital marketsEDGAR filings, XBRL, proxies, full-text search, antitrust notices, halts, and EOD quotes.
10 sources — show list
- End-of-day market quotes(Finnhub/Polygon)
- Finnhub — end-of-day market quotes(Finnhub)
- Healthcare antitrust / HSR (Federal Register)(FTC/DOJ)
- NASDAQ trading halts(NASDAQ)
- Polygon.io — end-of-day market quotes (US fallback)(Polygon)
- SEC DEF 14A proxy statements(SEC)
- SEC EDGAR filings index(SEC)
- SEC EDGAR full-text search(SEC)
- SEC primary document excerpts(SEC)
- SEC XBRL company facts(SEC)
Payer & accessCMS coverage & IRA, ICER HTA, EU HTA bundle, AMA CPT, and WHO essential medicines.
9 sources — show list
- AMA CPT / RUC coding policy(AMA)
- CMS Medicare coverage (NCD/LCD)(CMS)
- CMS Medicare drug affordability / IRA(CMS)
- CMS Part D & Medicaid open data(CMS)
- EU HTA guidance index (NICE, HAS, …)(EU)
- HRSA 340B / OPA policy(HRSA)
- ICER value assessments(ICER)
- Medicare Part D payment policy(CMS)
- WHO essential medicines list(WHO)
IP & exclusivityOrange Book, Purple Book, USPTO bulk, PTAB, and EPO legal status.
6 sources — show list
- EPO patent legal status / SPC context(EPO)
- FDA Orange Book (small-molecule exclusivity)(FDA)
- FDA Purple Book (biologics)(FDA)
- USPTO patent bulk index(USPTO)
- USPTO PTAB — proceedings portal(USPTO)
- USPTO PTAB decisions(USPTO)
Global regulators & filingsEMA EPAR, EU safety, ex-US agency indices, SEDAR+, Companies House, and ESMA.
10 sources — show list
- EMA EPAR summaries (English)(EMA)
- EMA PRAC & MHRA drug safety updates(EMA/MHRA)
- EMA quality guidelines (ICH-aligned)(EMA)
- ESMA EU parent issuers(ESMA)
- ICH harmonization guidelines(ICH)
- MHRA — UK medicines regulator(MHRA)
- PMDA, Health Canada, TGA, Swissmedic (English indices)
- SEDAR+ Canada filings index(CSA)
- UK Companies House(UK CH)
- US BIS export control guidance(BIS)
Science & literaturePubMed and preprint ingest; live PubMed, Europe PMC, and preprints on Engine and BoardMemos runs.
2 sources — show list
- bioRxiv / medRxiv preprints (ingest)
- PubMed pivotal publications (ingest)(NIH)
Policy & federal registerFederal Register, Regulations.gov, EUR-Lex pharma package, and thematic EPA surfaces.
6 sources — show list
- EPA facility / site search (supply themes)(EPA)
- EUR-Lex EU pharmaceutical legislation(EU)
- Federal Register documents API(US GPO)
- FTC — health privacy & data security cases(FTC)
- HHS HIPAA & health privacy policy(HHS)
- Regulations.gov dockets API(US GPO)
Pricing
Simple tiers
Free
Up to 3 active Watches
Prove the monitoring loop before you scale coverage across your portfolio.
Start free in SentinelPro - $49/month
Unlimited Watches
Full monitoring capacity for active deal teams - subscribe after you sign in to Sentinel.
Sign in to upgradeSocial proof
What leaders say
“Sentinel caught the exact regulatory filing that changed our licensing timeline.”
“Competitive intelligence that feels like it was written by someone who has actually done the deals.”
Next step